Cell cycle (Georgetown, Tex.), 2007-07, Vol.6 (14), p.1748-1752
2007
Details
- Autor(en) / Beteiligte
- Titel
- Aberrant Cytoplasmic Localization of N-CoR in Colorectal Tumors
- Ist Teil von
- Cell cycle (Georgetown, Tex.), 2007-07, Vol.6 (14), p.1748-1752
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Taylor & Francis Journals Auto-Holdings Collection
- Beschreibungen/Notizen
- We have previously shown that IKKs are aberrantly activated in colon cancer cells leading to SMRT phosphorylation and its release from the chromatin. We now show that IKKα phosphorylates the homologous N-CoR corepressor in serines 2345 and 2348 creating a functional 14-3-3 binding domain (RKpS2348KSP). Moreover, we have analyzed the subcellular localization of N-CoR in 43 colorectal cancer samples and we have found that aberrant cytoplasmic distribution of N-CoR is a general trait of these tumors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1538-4101eISSN: 1551-4005DOI: 10.4161/cc.6.14.4429Titel-ID: cdi_pubmed_primary_17630505
- Format
- –
- Schlagworte
- 14-3-3 Proteins - genetics, 14-3-3 Proteins - metabolism, Amino Acid Sequence, Binding, Biology, Bioscience, Calcium, Cancer, Cell, Cell Line, Tumor, Colon - cytology, Colon - metabolism, Colorectal Neoplasms - metabolism, Colorectal Neoplasms - pathology, Cycle, Cytoplasm - metabolism, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, Enzyme Activation, Humans, I-kappa B Kinase - genetics, I-kappa B Kinase - metabolism, Landes, Molecular Sequence Data, Nuclear Proteins - genetics, Nuclear Proteins - metabolism, Nuclear Receptor Co-Repressor 2, Organogenesis, Protein Structure, Tertiary, Proteins, Rectum - cytology, Rectum - metabolism, Repressor Proteins - genetics, Repressor Proteins - metabolism, Sequence Alignment, Serine - metabolism