Details

Autor(en) / Beteiligte

• Asakuma, S.(Obihiro Univ. of Agriculture and Veterinary Medicine, Hokkaido (Japan))
• Akahori, M
• Kimura, K
• Watanabe, Y
• Nakamura, T
• Tsunemi, M
• Arai, I
• Sanai, Y
• Urashima, T

Titel

Sialyl oligosaccharides of human colostrum: Changes in concentration during the first three days of lactation

Ist Teil von

• Bioscience, biotechnology, and biochemistry, 2007-06, Vol.71 (6), p.1447-1451

Ort / Verlag

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Sialyl oligosaccharides of human milk/colostrum are generally believed to be of biological significance, for example with respect to anti-adhesion of pathogenic organism, providing precursors for biosynthesis of brain, and so on. However, the levels of each of the sialyl oligosaccharides in human colostrum have not so far been determined. The present study was designed to determine the concentrations of nine major sialyl oligosaccharides in human colostrum, collected during the first 3d (days 1-3) from the start of lactation. We found that the concentration of 3'-sialyllactose was significantly higher on day 1 than on day 2 and 3, but the levels of 6'sialyllactose and sialyllacto-N-tetraose a were higher on day 3 than on day 1. These results are consistent with the view that during the first 3 d of lactation, the concentration of sialyl oligosaccharides in human colostrum change in accordance with the physiological demands of newborn infants.