Details

Autor(en) / Beteiligte

• Disney, J E
• Barth, A L
• Shultz, L D

Titel

Defective repair of radiation-induced chromosomal damage in scid/scid mice

Ist Teil von

• Cytogenetics and cell genetics, 1992, Vol.59 (1), p.39

Ort / Verlag

Switzerland

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of immunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display increased sensitivity to the damaging effects of ionizing radiation. We report here our observations of high frequencies of radiation-induced chromatid interchanges and intrachanges in bone marrow cells and fibroblasts from scid/scid mice. The presence of these aberrant chromosome structures suggests that a delay in strand rejoining underlies the increased sensitivity of scid/scid mice to ionizing radiation. The scid mutation may provide important clues for understanding the relationship between mitotic recombination and DNA repair in higher eukaryotic cells.