Details

Autor(en) / Beteiligte

• Zapletal, Alois
• Hladíková, Marie
• Chalupová, Jana
• Svobodová, Tamara
• Vávrová, Véra

Titel

Area under the Maximum Expiratory Flow-Volume Curve – A Sensitive Parameter in the Evaluation of Airway Patency

Ist Teil von

• Respiration, 2008-01, Vol.75 (1), p.40-47

Ort / Verlag

Basel, Switzerland: Karger

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: The most frequently used parameters for assessing bronchoconstriction and bronchodilation are forced expiratory volume in 1 s (FEV 1 ) and peak expiratory flow (PEF). Objectives: To assess the sensitivity of other parameters after induced bronchoconstriction and bronchodilation. Methods: From maximum expiratory flow-volume (MEFV) curves, forced vital capacity, FEV 1 , PEF, maximum expiratory flows (MEF) at 25, 50 and 75% of vital capacity and the area under the MEFV curve (A ex ) were measured in two groups of asthmatic children after induced bronchoconstriction and bronchodilation, and in children with cystic fibrosis (CF) after bronchodilation. Results: In 142 asthmatics without airway obstruction, bronchoconstriction was induced by inhalation of 1% histamine aerosol. The 20% fall in A ex compared to baseline was found in all asthmatics, while the 20 and 15% falls in FEV 1 were noted in 36 and 65% of the patients, respectively. Other parameters were less sensitive or interpretation was problematic. Another110 asthmatics with mild-moderate airway obstruction were treated with various bronchodilators. The 20% increase in A ex was observed in all asthmatics, while the 20% increase in FEV 1 was found in only 33% of the patients and the 15% increase in FEV 1 in 51%. In 9CF children, the pattern of changes in A ex and FEV 1 after bronchodilation was similar to that in asthmatics. Conclusions: A ex was a sensitive and less problematic parameter in the evaluation of airway patency in comparison with FEV 1 and other parameters measured from the MEFV curve in our study patients.