Details

Autor(en) / Beteiligte

• Ellis, R John

Titel

Protein misassembly: macromolecular crowding and molecular chaperones

Ist Teil von

• Advances in experimental medicine and biology, 2007, Vol.594, p.1

Ort / Verlag

United States

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• The generic tendency of proteins to misassemble into nonfunctional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This problem is exacerbated by the high total concentration of macromolecules found within most intracellular compartments but it is solved by the actions of molecular chaperones. This review discusses some of the basic evidence and key concepts relating to this conclusion.