Details

Autor(en) / Beteiligte

• Herrera-Goepfert, Roberto
• Yamamoto-Furusho, Jesus-K
• Onate-Ocana, Luis-F
• Camorlinga-Ponce, Margarita
• Munoz, Leopoldo
• Ruiz-Morales, Jorge-A
• Vargas-Alarcon, Gilberto
• Granados, Julio

Titel

Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

Ist Teil von

• World journal of gastroenterology : WJG, 2006-12, Vol.12 (48), p.7762

Ort / Verlag

United States

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method. We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14). HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.