Details

Autor(en) / Beteiligte

• Butterfield, D Allan
• Gnjec, Anastazija
• Poon, H Fai
• Castegna, Alessandra
• Pierce, William M
• Klein, Jon B
• Martins, Ralph N

Titel

Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment

Ist Teil von

• Journal of Alzheimer's disease, 2006-12, Vol.10 (4), p.391-397

Ort / Verlag

Netherlands

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• To identify oxidatively modified proteins in brains of persons with inherited Alzheimer's disease. Redox proteomics was used to identify oxidatively modified brain proteins in persons with mutations in the genes for presenilin-1 (PS-1). An initial redox proteomics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), gamma-enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. These initial results suggest that oxidatively modified proteins are important common features in both familial and sporadic AD.