Details

Autor(en) / Beteiligte

• BERKOVIC, Maja
• CACEV, Tamara
• ZJACIC-ROTKVIC, Vanja
• KAPITANOVIC, Sanja

Titel

TNF-α Promoter Single Nucleotide Polymorphisms in Gastroenteropancreatic Neuroendocrine Tumors

Ist Teil von

• Neuroendocrinology, 2006-01, Vol.84 (5), p.346-352

Ort / Verlag

Basel, Switzerland: Karger

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) secrete biogenic amines, hormones and growth factors, tumor necrosis factor-α (TNF-α) being one of them. As the expression of TNF-α is mostly regulated at the transcriptional level, its promoter polymorphisms have been intensively studied as a potential determinant of TNF-α production and cancer susceptibility. We have analyzed for the first time the potential association between -238, -308, -857 and -1031 TNF-α promoter polymorphisms and GEP-NETs. The study included 65 individuals diagnosed with GEP-NET and 154 healthy age- and sex-matched controls. Although most of the patients had solitary GEP-NETs, 6 were diagnosed with GEP-NET as a part of multiple endocrine neoplasia type 1 and 1 as a part of neurofibromatosis type 1. The C allele at the -1031 position was more frequent in GEP-NET patients (p < 0.0005), suggesting its possible role in GEP-NET development. The significant difference between foregut and midgut GEP-NET patients was observed in the -308 high expression genotypes and -308A allele (high expression) which tend to occur more frequently in the foregut GEP-NETs (p = 0.0392 and p = 0.0350, respectively). When functional and nonfunctional pancreatic endocrine tumors were compared, there were no significant differences in the researched TNF-α SNPs. The results suggest the putative role of TNF-α -1031 polymorphism in the development of GEP-NET.