Details

Autor(en) / Beteiligte

• Torsteinsdottir, Sigurbjorg
• Andresdottir, Valgerdur
• Arnarson, Hallgrimur
• Petursson, Gudmundur

Titel

Immune response to maedi-visna virus

Ist Teil von

• Frontiers in bioscience, 2007-01, Vol.12 (1), p.1532

Ort / Verlag

United States

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• The ovine maedi-visna virus (MVV) was the first lentivirus to be isolated and characterized 1957 in Iceland. MVV leads to a life-long, persistent infection with slow development of lesions in the lung and the central nervous system (CNS). The main target cells of MVV are of the monocyte/macrophage lineage and it does not infect T-lymphocytes or cause immune suppression like human immune deficiency virus (HIV). In spite of a fairly good immune response, including both neutralizing antibodies and cytotoxic T lymphocytes, the virus persists in the host and establishes a life-long infection. There are strong indications that the pathological lesions are immune-mediated and vaccination attempts have not only failed to induce sterile immunity but have occasionally caused increased viremia and more severe disease.