Antioxidants & redox signaling, 2007-02, Vol.9 (2), p.281-287
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
- Ist Teil von
- Antioxidants & redox signaling, 2007-02, Vol.9 (2), p.281-287
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1523-0864eISSN: 1557-7716DOI: 10.1089/ars.2007.9.281Titel-ID: cdi_pubmed_primary_17115943
- Format
- –
- Schlagworte
- alpha-Tocopherol - chemistry, Animals, Antioxidants - chemistry, Antioxidants - pharmacology, Antipyrine - analogs & derivatives, Antipyrine - pharmacology, Blood - metabolism, Brain Injuries - drug therapy, Free Radical Scavengers - pharmacology, Humans, Lipid Peroxidation, Neurons - pathology, Neuroprotective Agents - pharmacology, Nitric Oxide - chemistry, Rats, Reactive Oxygen Species, Time Factors