Details

Autor(en) / Beteiligte

• Fodor, Krisztina
• Léhman, Adrienn
• Perjési, Pál

Titel

Effect of some non-steroidal antiinflammatory drugs and isomeric dihydroxy benzoic acids on the AAPH initiated degradation of crocin

Ist Teil von

• Acta pharmaceutica Hungarica, 2006, Vol.76 (3), p.140

Ort / Verlag

Hungary

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• The authors examined the possible peroxyl radical scavanger effect of some non-steroidal antiinflammatory drugs and isomeric dihidroxy benzoic acids by means of the test based on 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-initiated degradation of crocin. The method is based on spectrophotometric determination of crocin, of which rate of AAPH-initiated degradation can be decreased in the presence of antioxidants with peroxyl radical scavanger activity. The authors studied the crocin degradation-inhibitory effect of phenacetin, paracetamol (acetaminophen), indomethacin, ibuprofen, diclofenac sodium, salicylic acid, salicylamide as well as the 2,3-, 2,4-, 2,5- and 3,4-dihydroxy substituted benzoic acids in 200 microM concentration. In the 60 minute studies the 2,3-, 2,5- and 3,4-dihydroxy benzoic acids proved to show the most effective degradation inhibitory effect. The results draw attention to the different antioxidant activity of salicylic acid and its hydroxylated metabolites (2,3- and 2,5-dihydroxy benzoic acids) formed under physiological conditions.