Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2006-10, Vol.26 (10), p.1449
2006
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- Autor(en) / Beteiligte
- Titel
- Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation
- Ist Teil von
- Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2006-10, Vol.26 (10), p.1449
- Ort / Verlag
- China
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To explore the possibility of repairing chemically induced acute hepatic injuries with allogeneic bone marrow stem cell (BMSC) transplantation. A SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination. Cellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation. Allogeneic BMSC transplantation can repair chemically induced acute liver injuries.
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1673-4254Titel-ID: cdi_pubmed_primary_17062349
- Format
- –
- Schlagworte
- Animals, Bone Marrow Cells - cytology, Carbon Tetrachloride - toxicity, Chemical and Drug Induced Liver Injury - etiology, Chemical and Drug Induced Liver Injury - pathology, Chemical and Drug Induced Liver Injury - surgery, Hematopoietic Stem Cell Transplantation - methods, Male, Random Allocation, Rats, Rats, Sprague-Dawley, Treatment Outcome