Details

Autor(en) / Beteiligte

• Hebel, Katrin
• Griewank, Klaus
• Inamine, Ayako
• Chang, Hyun-Dong
• Müller-Hilke, Brigitte
• Fillatreau, Simon
• Manz, Rudolf A
• Radbruch, Andreas
• Jung, Steffen

Titel

Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells

Ist Teil von

• European journal of immunology, 2006-11, Vol.36 (11), p.2912

Ort / Verlag

Germany

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Dendritic cells (DC) play an important role as antigen-presenting cells in T cell stimulation. Interestingly, a number of recent studies also imply DC as critical accessory cells in B cell activation, isotype switching and plasma blast maintenance. Here we use the conditional in vivo ablation of CD11c(high) DC to investigate the role of these cells in T-independent type 2 immune responses. We show that CD11c(high) DC are dispensable for the initiation and maintenance of a primary immune response against the T-independent type 2 antigen (4-hydroxy-3-nirophenyl)acetyl-Ficoll. Our results suggest that support for plasma cell formation in T cell-independent immune responses can be provided by non-DC such as stromal cells, or is independent of external signals. Interestingly, we found plasma blasts to express CD11c and to be diphtheria toxin-sensitive in CD11c-diphtheria toxin receptor-transgenic mice, providing a unique tool for future analysis of in vivo aspects of plasma cell biology.