Zhongguo zhongyao zazhi, 2006-05, Vol.31 (9), p.751
2006
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- Autor(en) / Beteiligte
- Titel
- Effect of prepared Polygonum multiflorum on striatum extracellular acetylcholine and choline in rats of intracerebral perfusion with sodium azide
- Ist Teil von
- Zhongguo zhongyao zazhi, 2006-05, Vol.31 (9), p.751
- Ort / Verlag
- China
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the protection mechanism of prepared Polygonum multiflorum (PPMT) in rat brain with sodium azide (NaN3) perfusion. Rats were divided into six groups: control, model, PPMT, Duxil and PPMT + Duxil groups. The intracerebral microdialysis and high performance liquid chromatography-post column Immobilized enzyme reactor-electrochemical detection were used to continuously measure extracellular acetylcholine (ACh) and choline (Ch) levels in striatum of freely moving awake rats. The extracellular Ach, Ch levels of striatum stayed stable in the control group during the whole observing period, but the ACh levels in the model group were lower significant than that in the control group. The Ach levels of three drug groups were respectively higher significant than that of model group at some time points. While the extracellular Ch level in striatum of the model group increased singnificantly compared with the control group. The Ch levels of the three drug groups were lower significant than that of the model
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1001-5302Titel-ID: cdi_pubmed_primary_17048685
- Format
- –
- Schlagworte
- Acetylcholine - metabolism, Animals, Choline - metabolism, Corpus Striatum - metabolism, Drugs, Chinese Herbal - isolation & purification, Drugs, Chinese Herbal - pharmacology, Male, Mitochondria - drug effects, Mitochondria - metabolism, Mitochondrial Diseases - chemically induced, Mitochondrial Diseases - metabolism, Neuroprotective Agents - isolation & purification, Neuroprotective Agents - pharmacology, Perfusion - adverse effects, Plants, Medicinal - chemistry, Polygonum - chemistry, Random Allocation, Rats, Rats, Sprague-Dawley, Sodium Azide