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Clinical significance of a multiple biomarker assay in patients with lung cancer. A study with logistic regression analysis
Ist Teil von
Chest, 1990-03, Vol.97 (3), p.639-644
Ort / Verlag
Northbrook, IL: American College of Chest Physicians
Erscheinungsjahr
1990
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The relative usefulness of a combination of some tumor markers, such as CEA, AFP, ferritin and NSE for the diagnosis of lung
cancer was assessed by multiple logistic analysis. Serum concentration of these markers was determined in 68 patients with
lung cancer (50 with NSCLC and 18 with SCLC, in 68 patients with benign lung disease and 75 normal control subjects. Ferritin
proved to be the most useful in diagnosing both NSCLC and SCLC, while NSE was found to be of some help in diagnosing SCLC
only. The multiple marker panel proved to be more sensitive and specific than any single marker in discriminating lung cancer
from normal control tissue, but it was of limited value in discriminating malignant from benign lung disease. The results
of the present study would suggest that the panel of investigated tumor markers is not of great help for the early diagnosis
of lung cancer.