Details

Autor(en) / Beteiligte

• Carpentier, C
• Laigle-Donadey, F
• Marie, Y
• Auger, N
• Benouaich-Amiel, A
• Lejeune, J
• Kaloshi, G
• Delattre, J-Y
• Thillet, J
• Sanson, M

Titel

Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma

Ist Teil von

• Neurology, 2006-09, Vol.67 (5), p.872

Ort / Verlag

United States

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.