Details

Autor(en) / Beteiligte

• Ogawa, M.(Josai Univ., Sakado, Saitama (Japan))
• Koyanagi, J
• Sugaya, A
• Tsuda, T
• Ohguchi, H
• Nakayama, K
• Yamamoto, K
• Tanaka, A

Titel

Cytotoxic activity toward KB cells of 2-substituted naphtho[2,3-b]furan-4,9-diones and their related compounds

Ist Teil von

• Bioscience, biotechnology, and biochemistry, 2006-04, Vol.70 (4), p.1009-1012

Ort / Verlag

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

Erscheinungsjahr

2006

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We investigated the cytotoxic activity of 2-substituted naphtho[2,3-b]furan-4,9-diones. We have previously synthesized 33 types of 2-substituted and related compounds, and the cytotoxic activity of these compounds was then examined by a KB cell culture assay. 2-(3-Furanoyl)benzoic acids and 1,4-naphthoquinones had no activity. 2-Acety1-4,9-dimethoxynaphtho[2,3-b]furan 4 showed low activity. However, parent naphtho[2,3-b]furan-4,9-dione 2 and most 2-substituted derivatives exhibited cytotoxic activity. The parent structure was therefore for cytotoxicity. 2-Formylnaphtho[2,3-b]furan-4,9-dione 11 had particularly potent activity (EDsub(50)=0.09 microg/ml).