Details

Autor(en) / Beteiligte

• Zheng, Shu-guo
• Feng, Xiao-bin
• He, Zhen-ping
• Qing, De-ke
• Leng, Jian-jun
• Dong, Jia-hong

Titel

Experimental study on tolerance time limits from warm ischemia to cold preservation of liver grafts

Ist Teil von

• Zhonghua gan zang bing za zhi, 2006-04, Vol.14 (4), p.250

Ort / Verlag

China

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the tolerance time limits from warm ischemia to cold preservation of liver grafts. Orthotopic liver transplantations (OLTs) were performed on Bama miniature swine. Morphological and functional changes of the liver grafts and biliary tracts after 10 minutes of warm ischemia followed by different durations of cold preservation and its reversibility were investigated. When the grafts were subjected to 10 minutes of warm ischemia followed by less than 16 hours of cold preservation, all animals could survive 1 week and there was no animal death from biliary necrosis. However, when the cold preservation time exceeded 16 hours, the incidence of biliary necrosis was significantly increased (P<0.05), and recipient death from bile leaks occurred. With further prolongation of the cold preservation time, primary graft nonfunction and intraoperative or early postoperative deaths occurred and the living animals all developed biliary necrosis. When compared with the less than 16 hours cold preservation group,