Details

Autor(en) / Beteiligte

• Liu, C J
• Tzeng, C H
• Liu, J H
• Chaou, S C
• Liu, J M
• Fan, S
• Hsieh, R K
• Liu, S M
• Tiu, C M
• Liu, R S

Titel

CA125 in non-Hodgkin's lymphoma

Ist Teil von

• Zhonghua yi xue za zhi (Taipei, Taiwan), 1991-11, Vol.48 (5), p.382

Ort / Verlag

China (Republic : 1949- )

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• CA125 is an antigenic determinant recognized by monoclonal antibody CA125 raised against a serous ovarian cancer cell line. Elevation of this antigen has been reported in over 80% of women with epithelial ovarian cancer and many other diseases including both malignant and non-malignant ones. However, in non-Hodgkin's lymphoma (NHL) only a few reports have focused on this topic thus interesting us. In order to exploit its possible role in this field, a total of 61 eligible patients with a diagnosis of NHL were studied. Serum CA125 was measured by radioimmunoassay (RIA) prior to any operative procedures or chemotherapy. Serum CA125 above 35 U/ml was seen in 47.7% of nodal NHL (n = 44) and 70.6% of extranodal NHL (n = 17) with an overall positive rate at 54.1%. The elevation of serum CA125 correlates well with the presence of peritoneal involvement and therefore, with disease extent to some degree. No correlation between it and the histological type or with the B symptom was the rule. Avidin-biotin peroxidase st