Details

Autor(en) / Beteiligte

• Glantz, M J
• Burger, P C
• Herndon, 2nd, J E
• Friedman, A H
• Cairncross, J G
• Vick, N A
• Schold, Jr, S C

Titel

Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas

Ist Teil von

• Neurology, 1991-11, Vol.41 (11), p.1741

Ort / Verlag

United States

Erscheinungsjahr

1991

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Stereotactic biopsy of CNS tumors provides a small amount of tissue for pathologic diagnosis. This potentially leads to inaccurate grading of gliomas because of their histologic heterogeneity. We compared histologic diagnoses in a consecutive series of 329 patients with newly diagnosed anaplastic gliomas whose diagnoses were established by either stereotactic biopsy or open resection. Of 262 patients undergoing resection, 214 (82%) had glioblastomas and 48 (18%) had anaplastic astrocytomas (AAs). Of 67 patients undergoing stereotactic biopsy, 33 (49%) had glioblastomas and 34 (51%) had AAs. This difference suggests that some AAs diagnosed by stereotactic biopsy are actually glioblastomas and has important implications for the design and interpretation of clinical trials.