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Integrity profiling of high throughput screening hits using LC-MS and related techniques
Ist Teil von
Combinatorial chemistry & high throughput screening, 2005-09, Vol.8 (6), p.459-466
Ort / Verlag
United Arab Emirates
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
Integrity profiling of HTS hits is valuable for verification of the hit identity and purity. This provides early discovery researchers with more confident SAR theories. Methodology for integrity profiling of HTS hits must be high throughput, consume little material, and selectively provide structure-based data. Analytical techniques that can be utilized for integrity profiling methods are reviewed for their appropriateness in sample preparation, component separation, detection, purity quantitation, identity confirmation, and follow-up.