Details

Autor(en) / Beteiligte

• Kerns, Edward H
• Di, Li
• Bourassa, Jim
• Gross, Jonathan
• Huang, Nelson
• Liu, Hanlan
• Kleintop, Teresa
• Nogle, Lisa
• Mallis, Larry
• Petucci, Chris
• Petusky, Susan
• Tischler, Mark
• Sabus, Chantel
• Sarkahian, Ani
• Young, Mairead
• Zhang, Mei-Yi
• Huryn, Donna
• McConnell, Oliver
• Carter, Guy

Titel

Integrity profiling of high throughput screening hits using LC-MS and related techniques

Ist Teil von

• Combinatorial chemistry & high throughput screening, 2005-09, Vol.8 (6), p.459

Ort / Verlag

United Arab Emirates

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Integrity profiling of HTS hits is valuable for verification of the hit identity and purity. This provides early discovery researchers with more confident SAR theories. Methodology for integrity profiling of HTS hits must be high throughput, consume little material, and selectively provide structure-based data. Analytical techniques that can be utilized for integrity profiling methods are reviewed for their appropriateness in sample preparation, component separation, detection, purity quantitation, identity confirmation, and follow-up.