Details

Autor(en) / Beteiligte

• Tiihonen, Jari
• Halonen, Pirjo
• Wahlbeck, Kristian
• Repo-Tiihonen, Eila
• Hyvärinen, Soile
• Eronen, Markku
• Putkonen, Hanna
• Takala, Pirjo
• Mehtonen, Olli-Pekka
• Puck, Martin
• Oksanen, Jorma
• Koskelainen, Pasi
• Joffe, Grigori
• Aer, Juhani
• Hallikainen, Tero
• Ryynänen, Olli-Pekka
• Tupala, Erkki

Titel

Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial

Ist Teil von

• The journal of clinical psychiatry, 2005-08, Vol.66 (8), p.1012-1015

Ort / Verlag

United States

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• We tested the hypothesis that topiramate is more effective than placebo in reducing symptoms in patients with treatment-resistant schizophrenia when combined with ongoing antipsychotic medication. Twenty-six hospitalized treatment-resistant patients with chronic DSM-IV-diagnosed schizophrenia participated in a randomized, double-blind, placebo-controlled trial in which 300 mg/day of topiramate was gradually added to their ongoing treatment (clozapine, olanzapine, risperidone, or quetiapine) over two 12-week crossover treatment periods. Data were collected from April 2003 to November 2003. In intention-to-treat analysis, topiramate was more effective than placebo in reducing Positive and Negative Syndrome Scale general psychopathologic symptoms (effect size = 0.7, p = .021), whereas no significant improvement was observed in positive or negative symptoms. Glutamate antagonist topiramate may be an effective adjuvant treatment in reducing general psychopathologic symptoms in patients with schizophrenia resistant to treatment with second-generation antipsychotics.