Neuropsychopharmacology (New York, N.Y.), 2005-08, Vol.30 (8), p.1492
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei
- Ist Teil von
- Neuropsychopharmacology (New York, N.Y.), 2005-08, Vol.30 (8), p.1492
- Ort / Verlag
- England
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The behavioral effects of peripherally administered interleukin-1beta (IL-1beta) are mediated by the production of cytokines and other proinflammatory mediators at the level of the blood-brain interface and by activation of neural pathway. To assess whether this action is mediated by NFkappaB activation, rats were injected into the lateral ventricle of the brain with a specific inhibitor of NFkappaB activation, the NEMO Binding Domain (NBD) peptide that has been shown previously to abolish completely IL-1beta-induced NFkappaB activation and Cox-2 synthesis in the brain microvasculature. NFkappaB pathway inactivation significantly blocked the behavioral effects of intraperitoneally administered IL-1beta in the form of social withdrawal and decreased food intake, and dramatically reduced IL-1beta-induced c-Fos expression in various brain regions as paraventricular nucleus, supraoptic nucleus, and lateral part of the central amygdala. These findings strongly support the hypothesis that IL-1beta-induced NFkappaB activation at the blood-brain interface is a crucial step in the transmission of immune signals from the periphery to the brain that underlies further events responsible of sickness behavior.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0893-133XTitel-ID: cdi_pubmed_primary_15900319
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Behavior, Animal, Body Weight - drug effects, Brain - anatomy & histology, Brain - drug effects, Brain - metabolism, Drug Interactions, Eating - drug effects, Enzyme Induction, Enzyme Inhibitors - pharmacology, Gene Expression Regulation, Enzymologic - drug effects, Gene Expression Regulation, Enzymologic - physiology, Immobility Response, Tonic - drug effects, Interleukin-1 - pharmacology, Male, NF-kappa B - antagonists & inhibitors, NF-kappa B - physiology, Proto-Oncogene Proteins c-fos - metabolism, Rats, Rats, Wistar, Signal Transduction - drug effects, Signal Transduction - physiology, Social Behavior, Time Factors