Details

Autor(en) / Beteiligte

• Vabre-Latre, C-M
• Bayle, P
• Marguery, M-C
• Gadroy, A
• Durand, D
• Bazex, J

Titel

Worsening of subacute lupus erythematosus induced by infliximab

Ist Teil von

• Annales de dermatologie et de vénéréologie, 2005-04, Vol.132 (4), p.349

Ort / Verlag

France

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• Infliximab (Remicade) is an anti-TNF alpha indicated in the treatment of chronic inflammatory rheumatism, notably rheumatoid arthritis. We report the case of a 56 year-old woman who developed severe worsening of an SSA-positive subacute lupus erythematosus on initiation of treatment with infliximab for rheumatoid arthritis. A review of the literature found 30 cases of drug-induced lupus and listed the autoimmune modifications induced by anti-TNF alpha. This first case of subacute lupus erythematosus, existing before the introduction of treatment and worsening during the latter, emphasizes the risk of developing a severe flare of an autoimmune disease during treatment with anti-TNF alpha. It raises the question of the relative contraindications of anti-TNF alpha in patients with lupus erythematosus.