Details

Autor(en) / Beteiligte

• Lee, W.S
• Kim, J.R
• Im, K.R
• Cho, K.H
• Sok, D.E
• Jeong, T.S

Titel

Antioxidant effects of diarylheptanoid derivatives from Alnus japonica on human LDL oxidation

Ist Teil von

• Planta medica, 2005-04, Vol.71 (4), p.295-299

Ort / Verlag

Germany

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Two diarylheptanoids, oregonin (1) and hirsutanone (2), were isolated by bioassay-guided fractionation of the methanol extracts of the leaves of ALNUS JAPONICA Steud and their structures were elucidated from their spectroscopic data. Compounds 1 and 2 exhibited significant low-density lipoprotein (LDL)-antioxidant activities, e. g., thiobarbituric acid-reactive substances (TBARS) assay (1: IC 50 = 3.2 μM, 2: IC 50 = 1.5 μM), lag time (1 : 162 min, 2 : 230 min at 2.0 μM, control: 63 min), relative electrophoretic mobility (REM, inhibition of 1 : 71 %, 2 : 75 % at 10 μM), apoB-100 fragmentation (inhibition of 1 : 27.3 %, 2 : 40.3 % at 10 μM) and macrophage-mediated LDL oxidation (inhibition of 1 : 82 %, 2 : 84 % at 1 μM).