Zhōnghuá zhŏngliú zázhì, 2004-11, Vol.26 (11), p.673
2004
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- Autor(en) / Beteiligte
- Titel
- mRNA expression of IGF-IIand HGF in relation to microvascular density, tumor progression and prognosis of gastric carcinoma
- Ist Teil von
- Zhōnghuá zhŏngliú zázhì, 2004-11, Vol.26 (11), p.673
- Ort / Verlag
- China
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate whether correlation exists between mRNA expression of IGF-II and hepatocyte growth factor (HGF) and tumor progression and prognosis in gastric cancer. In situ hybridization technique was used to examine mRNA expression of IGF-II and HGF, and immunohistochemical technique was used to examine protein expression of CD34 in 105 specimens of gastric carcinoma. In situ hybridization revealed that the positive rates of IGF-II mRNA and HGFmRNA were 49.5% and 57.1%, respectively. In stage T3-T4 cases, positive mRNA expression rates of IGF-II and HGF, the frequencies of vessel invasion, lymph node metastasis and distant metastasis were significantly higher than those in stage T1-T2 cases. The mean microvascular density (MVD) in stage T3-T4 tumors, vessel invasion, lymph node metastasis and distant metastasis were significantly more frequent than those in stage T1-T2 tumors. The mean MVD in tumors with positive IGF-II and HGF expressions was significantly higher than that in tumors without IGF-II and HGF
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0253-3766Titel-ID: cdi_pubmed_primary_15777506
- Format
- –
- Schlagworte
- Adenocarcinoma, Papillary - blood supply, Adenocarcinoma, Papillary - metabolism, Adenocarcinoma, Papillary - secondary, Adult, Aged, Carcinoma, Ductal - blood supply, Carcinoma, Ductal - metabolism, Carcinoma, Ductal - secondary, Carcinoma, Signet Ring Cell - blood supply, Carcinoma, Signet Ring Cell - metabolism, Carcinoma, Signet Ring Cell - secondary, Disease Progression, Female, Hepatocyte Growth Factor - biosynthesis, Hepatocyte Growth Factor - genetics, Humans, Insulin-Like Growth Factor II - biosynthesis, Insulin-Like Growth Factor II - genetics, Liver Neoplasms - blood supply, Liver Neoplasms - metabolism, Liver Neoplasms - secondary, Lymphatic Metastasis, Male, Microcirculation, Middle Aged, Neoplasm Invasiveness, Neovascularization, Pathologic, Peritoneal Neoplasms - blood supply, Peritoneal Neoplasms - metabolism, Peritoneal Neoplasms - secondary, Prognosis, RNA, Messenger - biosynthesis, RNA, Messenger - genetics, Stomach Neoplasms - blood supply, Stomach Neoplasms - metabolism, Stomach Neoplasms - pathology, Survival Rate