Details

Autor(en) / Beteiligte

• Carmona-Calero, E M
• Perez-Gonzalez, H
• Martinez-Peña Y Valenzuela, I
• Gonzalez-Marrero, I
• Perez-Garcia, C G
• Marrero-Gordillo, N
• Ormazabal-Ramos, C
• Castañeyra-Perdomo, A
• Ferres-Torres, R

Titel

Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats

Ist Teil von

• Histology and histopathology, 2005-01, Vol.20 (1), p.135

Ort / Verlag

Spain

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using anti-angiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment.