Details

Autor(en) / Beteiligte

• Vovk, A I
• Kharchenko, O V
• Kharitonenko, A I
• Kukhar', V P
• Babiĭ, L B
• Kazachkov, M G
• Mel'nik, A K
• Khil'chevskiĭ, A N

Titel

Hydrophobic nitroxyl radicals inhibit linoleyl alcohol oxidation by 5-lipoxygenase

Ist Teil von

• Bioorganicheskaia khimiia, 2004-07, Vol.30 (4), p.436

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• The linoleyl alcohol oxidation catalyzed by potato tuber 5-lipoxygenase was found to be efficiently inhibited by stable nitroxyl radicals: 1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl 1-bicyclo[2,2,2]octane-1-carboxylate, 1-adamantylacetate, dodecanoate, and octadecanoate. The dependence of apparent IC50 values on the rotational correlation times of times of 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine and its derivatives in model micellar systems was analyzed. The inhibition mechanism was proposed; it involves the interaction of hydrophobic nitroxyl radical with the intermediate radical enzyme-substrate complex.