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Clinics in liver disease, 2004-11, Vol.8 (4), p.775-785
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2004
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Intrahepatic iron overload is commonly seen in chronic hepatitis C infection. High levels of intrahepatic iron may lead to accelerated liver injury and development of fibrosis and cirrhosis. This is frequently seen in hereditary hemochromatosis, which in most of the cases is caused by homozygous mutations in the
HFE gene. In patients suffering from chronic hepatitis C, the presence of heterozygous
HFE mutations associates with higher hepatic iron scores and advanced stages of fibrosis.
HFE mutations must therefore be considered as important comorbidity factors in chronic hepatitis C infection.