Chung-hua nei kʿo tsa chih, 2004-08, Vol.43 (8), p.595
2004
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- Autor(en) / Beteiligte
- Titel
- Influence of N-acetylcysteine on the cytokines and matrix metalloproteinases in chronic obstructive pulmonary disease rat models
- Ist Teil von
- Chung-hua nei kʿo tsa chih, 2004-08, Vol.43 (8), p.595
- Ort / Verlag
- China
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the changes of interferon-gamma (IFNgamma), interleukin (IL)-4, matrix metalloproteinase (MMP)-9, MMP-12 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in smoke-induced chronic obstructive pulmonary disease (COPD) rat models and the therapeutic effect of N-acetylcysteine (NAC). Male Wistar rats were exposed to cigarette smoke for 3.5 months. NAC was given in the last month. Lung function was measured at the end of the study. The levels of IL-4 and IFNgamma in broncho-alveolar lavage fluid (BALF) and lung tissues were determined by ELISA. The expression of MMP-9, MMP-12 and TIMP-1 mRNA in lung tissues were determined by RT-PCR. (1) In comparison with the control group, smoke exposed group presented a significant decrease in forced expiratory volume in 0.3 second (FEV(0.3))/forced vital capacity (FVC), dynamic lung compliance (Cdyn), mean alveolar numbers (MAN) and a significant increase in expiratory resistance (Re), pulmonary mean linear intercept (Lm) (P < 0.05). After treatment wit
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0578-1426Titel-ID: cdi_pubmed_primary_15355665
- Format
- –
- Schlagworte
- Acetylcysteine - pharmacology, Animals, Disease Models, Animal, Interferon-gamma - metabolism, Interleukin-4 - metabolism, Male, Matrix Metalloproteinase 12, Matrix Metalloproteinase 9 - metabolism, Metalloendopeptidases - metabolism, Pulmonary Disease, Chronic Obstructive - metabolism, Pulmonary Disease, Chronic Obstructive - physiopathology, Rats, Rats, Wistar, Tissue Inhibitor of Metalloproteinase-1 - metabolism, Tobacco Smoke Pollution