Zhong hua yi xue za zhi, 2004-07, Vol.84 (13), p.1066
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Advanced glycation end products accelerate atherosclerosis via enhancement of oxidative stress
- Ist Teil von
- Zhong hua yi xue za zhi, 2004-07, Vol.84 (13), p.1066
- Ort / Verlag
- China
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the effect of advanced glycation end products (AGE) on atheromatous plaque formation and its possible mechanisms. Fifty rabbits were randomly divided into five groups of 10 rabbits: group A, fed with hypercholesterolemic diet and injected intravenously with AGE modified rabbit serum albumin (AGE-RSA); group B, fed with hypercholesterolemic diet and injected with unmodified RSA; group C, fed with hypercholesterolemic diet; group D, fed with normal diet alone: and group E, fed with normal diet and injected with AGE-RSA. Ten weeks after the rabbits were killed. Their aortas were taken out and stained with Sudan red IV. The extent of atheromatous plaques in the aortas en face was evaluated by computer-assisted morphometry and by histologic examination. Photoshop system was used to measure the percentage of atheromatous plaques in the area of tunica intima. The depositions of AGE, malondialdehyde modified low-density lipoprotein (MDA-LDL), oxidized low-density lipoprotein (ox-LDL) and expression of
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0376-2491Titel-ID: cdi_pubmed_primary_15312503
- Format
- –
- Schlagworte
- Animals, Arteriosclerosis - blood, Arteriosclerosis - etiology, Cholesterol, Dietary - toxicity, Diet, Atherogenic, Glycation End Products, Advanced - blood, Glycation End Products, Advanced - toxicity, Hypercholesterolemia - complications, Lipids - blood, Male, Oxidative Stress - drug effects, Rabbits, Random Allocation, Reactive Oxygen Species - metabolism