Details

Autor(en) / Beteiligte

• BACCI, Simonetta
• MENZAGHI, Claudia
• TRISCHITTA, Vincenzo
• ERCOLINO, Tonino
• XIAOWEI MA
• RAUSEO, Anna
• SALVEMINI, Lucia
• VIGNA, Carlo
• FANELLI, Raffaele
• DI MARIO, Umberto
• DORIA, Alessandro

Titel

The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients

Ist Teil von

• Diabetes care, 2004-08, Vol.27 (8), p.2015-2020

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients Simonetta Bacci , MD 1 , Claudia Menzaghi , PHD 1 , Tonino Ercolino , MD 1 2 , Xiaowei Ma , MD 2 , Anna Rauseo , MD 1 , Lucia Salvemini , BSC 1 , Carlo Vigna , MD 1 , Raffaele Fanelli , MD 1 , Umberto Di Mario , MD 3 , Alessandro Doria , MD, PHD 2 and Vincenzo Trischitta , MD 1 3 1 Cardiovascular and Endocrine Department of the Scientific Institute, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy 2 Research Division, Joslin Diabetes Center, Boston, Massachusetts 3 Department of Clinical Sciences, University La Sapienza, Rome, Italy Address correspondence and reprint requests to Dr. Simonetta Bacci, Casa Sollievo della Sofferenza, Scientific Institute, Unit of Endocrinology, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy. E-mail: endocrino{at}operapadrepio.it Abstract OBJECTIVE —Two single nucleotide polymorphisms (SNPs) at the adiponectin locus (+45T>G and +276G>T) have been associated with low circulating adiponectin levels, insulin resistance, and type 2 diabetes. We investigated whether these genetic markers are determinants of coronary artery disease (CAD) in type 2 diabetic patients. RESEARCH DESIGN AND METHODS —A total of 376 consecutive type 2 diabetic patients were studied: 142 case subjects with coronary stenosis >50% or previous myocardial infarction and 234 control subjects with no symptoms, no electrocardiogram (ECG) signs of myocardial ischemia, and a normal ECG stress test ( n = 189) and/or ( n = 45) with coronary stenosis ≤50%. RESULTS —No association with CAD was observed for the +45 SNP ( P = 0.48). By contrast, a significant association was observed for the +276 SNP, with T/T homozygotes having a lower risk of CAD than carriers of other genotypes (adjusted odds ratio [OR] 0.13 [95% CI 0.037–0.46], P = 0.002). A similarly protective effect of the +276 T/T genotype was observed in 110 case and 45 control subjects for whom the CAD status had been determined by angiography (0.04 [0.006–0.30], P = 0.002).  Serum adiponectin, although clearly related to several features of the proatherogenic/insulin-resistant phenotype, was not different between control subjects and CAD patients (26 ± 17 vs. 25 ± 13 μg/ml). CONCLUSIONS —In conclusion, the +276 G>T polymorphism is a determinant of CAD risk in type 2 diabetic patients. This marker may assist in the identification of diabetic individuals at especially high risk of CAD, so that preventive programs can be targeted at these subjects. AER, albumin excretion rate CAD, coronary artery disease ECG, electrocardiogram NF, nuclear factor RIA, radioimmunoassay SNP, single nucleotide polymorphism Footnotes A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. Accepted May 8, 2004. Received January 15, 2004. DIABETES CARE