Details

Autor(en) / Beteiligte

• Kalinina, Olga V
• Novichkov, Pavel S
• Mironov, Andrey A
• Gelfand, Mikhail S
• Rakhmaninova, Aleksandra B

Titel

SDPpred: a tool for prediction of amino acid residues that determine differences in functional specificity of homologous proteins

Ist Teil von

• Nucleic acids research, 2004-07, Vol.32 (Web Server issue), p.W424-W428

Ort / Verlag

England

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• SDPpred (Specificity Determining Position prediction) is a tool for prediction of residues in protein sequences that determine the proteins' functional specificity. It is designed for analysis of protein families whose members have biochemically similar but not identical interaction partners (e.g. different substrates for a family of transporters). SDPpred predicts residues that could be responsible for the proteins' choice of their correct interaction partners. The input of SDPpred is a multiple alignment of a protein family divided into a number of specificity groups, within which the interaction partner is believed to be the same. SDPpred does not require information about the secondary or three-dimensional structure of proteins. It produces a set of the alignment positions (specificity determining positions) that determine differences in functional specificity. SDPpred is available at http://math.genebee.msu.ru/~psn/.