Xi bao yu fen zi mian yi xue za zhi, 2003-09, Vol.19 (5), p.421
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of intracellular Ca(2+)-chelating agent on Hela cell apoptosis induced by HSV-1
- Ist Teil von
- Xi bao yu fen zi mian yi xue za zhi, 2003-09, Vol.19 (5), p.421
- Ort / Verlag
- China
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To explore the variation of intracellular free-Ca (2+) concentration during Hela cell apoptosis induced by HSV-1 and inhibition of Ca(2+)-chelating agent on the apoptosis. Apoptosis of the Hela cells infected by HSV-1 was observed under scanning electron microscope (SEM) and transmission electron microscope (TEM), and the variation of intracellular free-Ca (2+) concentration, labeled with fluorescent probe was observed under fluorescence-microscope at a series of timepoints. The Hela cells infected by HSV-1 showed typical apoptotic morphological changes. Free-Ca (2+) concentration increased and reached peak at the 12 hours after HSV-1 infection. Characteristic morphological features of apoptosis occurred at the 24 hours after infection. This apoptosis could be inhibited by intracellular Ca(2+)-chelating agent. Intracellular free-Ca(2+) might play an important role in Hela cell apoptosis induced by HSV-1, which provides useful clues for clinical treatment of associated diseases.
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1007-8738Titel-ID: cdi_pubmed_primary_15169644