Details

Autor(en) / Beteiligte

• TUBIANA MATHIEU, N
• GENET, D
• LABROUSSE, F
• BOUILLET, P
• LAVAU DENES, S
• MARTIN, J
• LABOUREY, J. L
• VENAT, L
• CLAVERE, P
• MOREAU, J. J

Titel

Pre-irradiation Chemotherapy for Newly Diagnosed High Grade Astrocytoma

Ist Teil von

• Anticancer research, 2004-03, Vol.24 (2C), p.1249-1253

Ort / Verlag

Attiki: International Institute of Anticancer Research

Erscheinungsjahr

2004

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The purpose of this work was to determine the response rate and toxicity of a combination of Carmustine and Cisplatin administered before radiation in patients with newly diagnosed high grade astrocytoma. A good response rate has been published with this association in primary cerebral high grade tumor. This protocol was administered in a homogeneous population of 37 adult patients with measurable tumor on magnetic resonance imaging (MRI) or CT scan. After biopsy or subtotal resection, the patients received BCNU 40 mg/m 2 /d and CODP 40 mg/m 2 /d, for 3 days every 28 days for 3 cycles. Evaluation was performed before each cycle. Radiation therapy began 4 weeks after completing the chemotherapy or immediately if there was evidence of tumor progression on chemotherapy. Seven out of 37 (19%) demonstrated tumor regression with a median duration to progression of 11 months. Median survival was 6 months. Myelosupression was the predominant but manageable toxicity. This work indicated that the first chemotherapy protocol gave poor results in a homogeneous group of patients, with bad prognosis.