Ai zheng = Aizheng = Chinese journal of cancer, 2004-04, Vol.23 (4), p.430
2004
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- Autor(en) / Beteiligte
- Titel
- Effects of combination therapy with all-trans retinoic acid and arsenic trioxide on acute promyelocytic leukemia
- Ist Teil von
- Ai zheng = Aizheng = Chinese journal of cancer, 2004-04, Vol.23 (4), p.430
- Ort / Verlag
- China
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The mechanism of effect of arsenic trioxide on promyelocytic leukemia is different from that of all-trans retinoic acid. Arsenic trioxide exerts its action by accelerating cell apoptosis, while all-trans retinoic acid by inducing cell differentiation. However, both drugs can inhibit the transcription of tissue factor (TF) mRNA in acute promyelocytic leukemia, and decrease TF level and coagulative activity to normalize coagulopathy. The objective of the study was to observe whether combination of the two drugs could improve efficacy or in contrary accentuate adverse reactions. Two groups of patients with acute promyelocytic leukemia were included. Twenty-two patients (17 untreated cases and 5 relapsed cases) from January 2000 to October 2001 in group I were treated only with oral retinoic acid [25 mg/(m(2)x d) in two divided doses] for less than 50 days. Nineteen cases (15 untreated cases and 4 relapsed cases) from November 2001 to June 2003) in Group II were treated with combination of arsenic trioxide and al
- Sprache
- Chinesisch
- Identifikatoren
- Titel-ID: cdi_pubmed_primary_15087033
- Format
- –
- Schlagworte
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols - adverse effects, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Arsenicals - administration & dosage, Blood Coagulation - drug effects, Female, Humans, Leukemia, Promyelocytic, Acute - blood, Leukemia, Promyelocytic, Acute - drug therapy, Male, Middle Aged, Oxides - administration & dosage, Tretinoin - administration & dosage