Details

Autor(en) / Beteiligte

• Chen, Yang
• Hu, Hua-zi
• Wu, Jia-wen
• Peng, Qi-yi
• Yang, Guo
• Liao, Zhi-gang

Titel

Changes of connexin 43 in rabbit with early myocardial ischemia

Ist Teil von

• Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2004-03, Vol.35 (2), p.191

Ort / Verlag

China

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• To reveal gap junction connexin 43 (Cx43) in rabbit with early myocardial ischemia. The left coronary arteries were ligated to create early myocardial ischemia. Cx43 was visualized by use of SP immunohistochemical method (IHC) and Colloidal gold of the electron microscopy, and a comparison was made between the experiment group and the control group. The semi-quantitation assessment was performed. The positive areas of Cx43 gap junctions by IHC and Colloidal gold particles of the electron microscopy were found decreased by about 40% at 30 minutes of acute myocardial ischemia. The distributions were not obviously modified. The decrease of Cx43 is characterized by the time during myocardial ischemia, and the early stage of acute myocardial ischemia in rat is of positive significance.