Details

Autor(en) / Beteiligte

• Cao, Fu-xian
• Liu, Tian-jia
• Yang, De-qin
• Pan, Ju-li

Titel

Research of immunization with recombinant plasmid pcDNA3-pacA and pcDNA3-pacP against dental caries in gnotobiotic rats. I: Measurement of specific anti-PAc S-IgA, IgG, valence

Ist Teil von

• Shanghai kou qiang yi xue, 2003-02, Vol.12 (1), p.34

Ort / Verlag

China

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, rats were immunized with pcDNA3-pacA and pcDNA3-pacP through submandibular gland, the valence of specific anti-PAc S-IgA,IgG were measured. Gnotobiotic rats were vaccinated with pcDNA3-pacA, pcDNA3-pacP and combination use of pcDNA3-pacA and pcDNA3-pacP through submandibular gland. The valence of specific anti-PAc S-IgA in salivary, IgG in serum were measured. The specific anti-PAc S-IgA, IgG could be detected in all of recombinant plasmid groups. The level of salivary specific anti-PAc S-IgA and IgG in pcDNA3-pacA, pcDNA3-pacP, combination use of pcDNA3-pacA and pcDNA3-pacP groups were higher than negative control groups (P < 0.05). The recombinant plasmid pcDNA3-pacA and pcDNA3-pacP could provoke specific mucosal immune responses as a novel immunogen against dental caries.