Zhōnghuá liúxíngbìng zázhì, 2003-09, Vol.24 (9), p.815
2003
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Study on the genetic association between DRB3 and DRB1 loci in the human MHC region and psychotic symptoms of schizophrenia
- Ist Teil von
- Zhōnghuá liúxíngbìng zázhì, 2003-09, Vol.24 (9), p.815
- Ort / Verlag
- China
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The genomic region of the human major histocompatibility complex (MHC) is located in the short arm of chromosome 6 (6p). Linkage studies have shown that the 6p region may contain a gene for schizophrenia, the MHC region has thus become particularly important in searching for the schizophrenia susceptibility gene. The present study was designed to investigate the genetic association of DRB3 and DRB1 genes with psychotic symptoms of schizophrenia. PCR-based restriction fragment length polymorphism (RFLP) analysis was applied to genotype two single nucleotide polymorphisms (SNPs) located in the DRB3 locus and in the DRB1 one in 116 Chinese Han family trios consisting of fathers, mothers and affected offspring with schizophrenia. Chi-square (chi(2)) test and haplotype-based relative risk (HRR) analysis were used on genotyping data. Data on HRR analysis did not show a genetic association either between the DRB3 locus and schizophrenia or between the DRB1 locus and the illness. However, the SNP rs707954, a G to T b
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0254-6450Titel-ID: cdi_pubmed_primary_14521776