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Effects of loading on the synthesis of proteoglycans in different layers of anatomically intact articular cartilage in vitro
Ist Teil von
Journal of rheumatology, 1992-06, Vol.19 (6), p.905
Ort / Verlag
Canada
Erscheinungsjahr
1992
Quelle
MEDLINE
Beschreibungen/Notizen
The anatomically intact articular cartilage (approximately equal to 2.5 cm2) of whole bovine sesamoid bones was cultured on its bone support. A load of 5 kg was applied intermittently at 0.3 Hz by a specially designed loading apparatus for 7 days. [35S]-sulfate was added during the last 17 h of the experiment. Loading induced a 40% increase in [35S]-sulfate incorporation into aggrecans and an almost 3-fold increase in the synthesis of small proteoglycans. The loading effects occurred mainly in the upper half of the articular cartilage. Samples left unloaded for 7 days and then loaded for 7 days likewise showed an increase in [35S]-sulfate incorporation compared with unloaded controls.