Details

Autor(en) / Beteiligte

• Ottaviani, E
• Caselgrandi, E
• Fontanili, P
• Franceschi, C

Titel

Evolution, immune responses and stress: studies on molluscan cells

Ist Teil von

• Acta biologica Hungarica, 1992, Vol.43 (1-4), p.293

Ort / Verlag

Hungary

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• Using a variety of techniques we found the presence of ACTH and opioid-like molecules in the phagocytic spreading hemocytes (SH) and the serum of the mollusc Planorbarius corneus. In vitro experiments have shown that ACTH and beta-endorphin exert chemotactic activity on SH, while ACTH, but not beta-endorphin increases the phagocytic activity of SH. Moreover, ACTH and CRF provoked the release of biogenic amines from the hemocytes, mimicking a proto-stress type of response. Thus, the same mobile cell is capable of immune and proto-stress responses by using as mediators neuropeptides which remained fundamentally similar throughout evolution.