Details

Autor(en) / Beteiligte

• VELDERS, MARKWIN P.
• MARKIEWICZ, MARY A.
• EIBEN, GRETCHEN L.
• MARTIN KAST, W.

Titel

CD4 + T CELL MATTERS IN TUMOR IMMUNITY

Ist Teil von

• International reviews of immunology, 2003-03, Vol.22 (2), p.113-140

Ort / Verlag

England: Informa UK Ltd

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• CD4 + T cells have been shown to be able to affect tumor growth through both direct and indirect means. In addition, a requirement has been demonstrated for CD4 + T cells in the regulation and induction of T cell memory, and CD4 + suppressor T cells have been identified, stressing a role for CD4 + T cells in the induction and maintenance of antitumor immune responses. A review of the involvement of CD4 + T cells at different stages of tumor immunity is provided, and based on these data we discuss how CD4 + T cell response induction could be incorporated into tumor immunotherapy strategies. dendritic cells suppressor T cells T cell memory CD4 + T cells tumor immunology