Reviews in the neurosciences, 2003, Vol.14 (1-2), p.63
2003
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Wiring the olfactory bulb--activity-dependent models of axonal targeting in the developing olfactory pathway
- Ist Teil von
- Reviews in the neurosciences, 2003, Vol.14 (1-2), p.63
- Ort / Verlag
- Germany
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Two recent experimental studies /20,21/ revealed that odorant-evoked activity-dependent competition is significant in the organisation and maintenance of the olfactory system. In this paper, we investigate the generation of a chemotopic sensory map in the olfactory bulb through three models driven by high-density optical chemosensor arrays which have similar properties to olfactory receptor neurons. By exposing the sensor arrays to various odours, these models were subjected to Hebbian learning to achieve self-organisation, potentially explaining the activity-dependent competition demonstrated by these recent studies. Our final model also predicts a role for periglomerular cells in the formation of the chemotopic sensory map in the olfactory bulb.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0334-1763eISSN: 2191-0200DOI: 10.1515/REVNEURO.2003.14.1-2.63Titel-ID: cdi_pubmed_primary_12929919
- Format
- –
- Schlagworte
- Animals, Axons - physiology, Brain Mapping, Cluster Analysis, Computer Simulation, Evoked Potentials - physiology, Mice, Models, Neurological, Neuronal Plasticity, Odorants, Olfactory Bulb - physiology, Olfactory Pathways - cytology, Olfactory Pathways - growth & development, Olfactory Pathways - physiology, Olfactory Receptor Neurons - physiology, Oligonucleotide Array Sequence Analysis - methods, Receptors, Odorant - physiology, Signal Transduction, Synapses - physiology