Details

Autor(en) / Beteiligte

• Kwon, C.S. (Kyungpook National Univ., Taegu (Korea R.))
• Sohn, H.Y
• Kim, S.H
• Kim, J.H
• Son, K.H
• Lee, J.S
• Lim, J.K
• Kim. J.S

Titel

Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents

Ist Teil von

• Bioscience, biotechnology, and biochemistry, 2003-07, Vol.67 (7), p.1451-1456

Ort / Verlag

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• In the process of screening for pancreatic lipase inhibitors, which could be used as an anti-obesity measure, the methanol extract of Dioscorea nipponica Makino powder (DP) appeared to have potent inhibitory activity against porcine pancreatic lipase with an IC sub(50) value of 5-10 microg/ml, where the enzyme activity was assayed by using 4-methylumbelliferyl oleate as a substrate. Further purification of active components present in the herb generated dioscin that belongs to the saponin family. Dioscin and its aglycone, diosgenin, both suppressed the time-dependent increase of blood triacylglycerol level when orally injected with corn oil to mice, suggesting their inhibitory potential against fat absorption. Sprague-Dawley rats fed on a high-fat diet containing 5% Dioscorea nipponica Makino and 40% beef tallow gained significantly less body weight and adipose tissue than control animals fed on a high-fat diet alone during an 8-week experimental period (P<0.05).