Details

Autor(en) / Beteiligte

• Kawano, Fuminori
• Nomura, Takeshi
• Ishihara, Akihiko
• Nonaka, Ikuya
• Ohira, Yoshinobu

Titel

Effects of chronic hindlimb suspension on landing performance in response to head-down drop in rats

Ist Teil von

• Uchu koku kankyo igaku, 2002-06, Vol.39 (2), p.21

Ort / Verlag

Japan

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• Effects of hindlimb unloading and reloading on the patterns of landing and posture adjustment in response to head-down drop from a height of approximately 30 cm were investigated in rats. Seven weeks old male Wistar rats were hindlimb-unloaded by tail suspension for 9 consecutive weeks. Motor tests were performed immediately after the termination of suspension and recovery patterns were checked during 8 weeks of ambulation recovery. Although all of the control rats were able to land smoothly by using the four limbs as the shock absorber, the unloaded rats landed by hitting their abdomen. The hindlimb-unloaded, but not control, rats dorsi-flexed their trunk during fall. The mean angle of abdominal side was approximately 145 degrees in control and approximately 215 degrees in unloaded rats. Even though such phenomena were maintained for approximately 12 hours, the response of the trunk angle recovered significantly 2 days later. However, it was not normalized completely even after 8 weeks. Hyper-extension of ankle joints and eversion of hindlimbs at landing were also noted in the unloaded rats. These phenomena were not recovered at all. It was generally suggested that severe detrimental effects on the landing performance of rats are induced following 9-weeks of suspension. And some of the responses are irreversible.