Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Toward the Genetics of Mammalian Reproduction: Induction and Mapping of Gametogenesis Mutants in Mice
Ist Teil von
Biology of reproduction, 2003-11, Vol.69 (5), p.1615-1625
Ort / Verlag
Madison, WI: Society for the Study of Reproduction
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility.
To further the discovery of genes required for mammalian gametogenesis, phenotype-driven screens were performed in mice using
random chemical mutagenesis of whole animals and embryonic stem cells. Eleven initial mutations are reported here that affect
proliferation of germ cells, meiosis, spermiogenesis, and spermiation. Nine of the mutations have been mapped genetically.
These preliminary studies provide baselines for estimating the number of genes required for gametogenesis and offer guidance
in conducting new genetic screens that will accelerate and optimize mutant discovery. This report demonstrates the efficacy
and expediency of mutagenesis to identify new genes required for mammalian gamete development.