Details

Autor(en) / Beteiligte

• Lai, Hsien Yong
• Yang, Cheryl C H
• Huang, Fan-Yen
• Lee, Yi
• Kuo, Yu Ling
• Kuo, Terry B J

Titel

Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system

Ist Teil von

• Clinical science (1979), 2003-10, Vol.105 (4), p.491-497

Ort / Verlag

England

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• During positive pressure mechanical ventilation, percentile systolic pressure variation (%SPV) or respiratory-related arterial pressure variability (RAPV) have both been used in assessment of graded haemorrhage. We aimed to investigate whether changes in %SPV and RAPV are correlated during graded haemorrhage (by 5, 10 or 20% of the estimated blood volume) in anaesthetized positive pressure ventilated rats and to investigate the involvement of autonomic regulation. Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage. Propranolol significantly decreased baseline %SPV and RAPV and changes induced in %SPV and RAPV by graded haemorrhage. Phentolamine significantly enhanced baseline %SPV and RAPV, and further enhancement of %SPV and RAPV by graded haemorrhage did not occur until 20% of the estimated blood volume was removed. RAPV was significantly correlated with %SPV in all experimental groups. We conclude that RAPV is comparable with%SPV as an indicator of graded haemorrhage and that, in anaesthetized and positive pressure ventilated rats, both are dependent on autonomic function, especially beta-adrenoceptors.