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Blood lymphocyte dehydrogenase activity (SDH, LDH, mitochondrial and cytoplasmic alpha-glycerophosphate dehydrogenase, NADH-diaphorase) was studied in 140 Wistar rats at different time intervals following intraosseous insertion of titanium implants. It was shown that implantation was accompanied with an increase in enzyme activities indicating a rise in the intensity of energy production processes. Cytochemical analysis of lymphocyte enzymes enables to formulate a "prognostic scenario" describing titanium implant interaction with biological environmental factors and organism tissues to assess the long-term results of implantation.