Details

Autor(en) / Beteiligte

• Chirenje, Z M
• Loeb, L
• Mwale, M
• Nyamapfeni, P
• Kamba, M
• Padian, N

Titel

Association of cervical SIL and HIV-1 infection among Zimbabwean women in an HIV/STI prevention study

Ist Teil von

• International journal of STD & AIDS, 2002-11, Vol.13 (11), p.765-768

Ort / Verlag

England

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• A cross-sectional study was conducted on women attending family planning clinics in Harare, Zimbabwe to determine the prevalence of cervical neoplasia among HIV-1 positive women relative to an HIV-1 negative control group. Five hundred and fifty four women were recruited and the prevalence of HIV-1 was 36.8%. Cervical cytology was abnormal in 25.6% of HIV-infected women compared to only 6.7% HIV-1 seronegative women. Cervical neoplasia was significantly associated with HIV infection (chi(2)=42.4, P<0.001). Cellular changes typical of HPV infection (koilocytocis) were recorded in 6.4% of HIV infected women compared with 1.7% of HIV-1-uninfected women (chi(2)=8.43, P=0.004). HIV-1-positive women had twice the risk of having abnormal cervical cells than HIV-negative women (relative risk 2.47, odds ratio 10.14, P<0.001). Therefore the introduction of national cervical screening programme in HIV-1 endemic countries like Zimbabwe where the highest burden of pre-malignant lesions is among HIV-1-infected women needs careful planning because these women have other competing health needs including high rates of opportunistic infections.